Tag Archives: Vibrio cholerae

DNA Replication – Frequent Words, Reverse Complement, Pattern Matching, Clump Finding, Skewi, Mismatches

Genome replication is one of the most important tasks carried out in the cell. Before a cell can divide, it must first replicate its genome so that each of the two daughter cells inherits its own copy.

Replication begins in a genomic region called the replication origin (denoted oriC) and is carried out by molecular copy machines called DNA polymerases.

Locating oriC presents an important task not only for understanding how cells replicate but also for various biomedical problems. For example, some gene therapy methods use genetically engineered mini-genomes, which are called viral vectors because they are able to penetrate cell walls (just like real viruses). Viral vectors carrying artificial genes have been widely used in agriculture.
In the following problem, we assume that a genome has a single oriC. Read more of this post